Kidney Function

Authors: Yoshioka K, Amino M, Matsuzaki A, Shima M, Fujii T, Kanda S, Deguchi Y, Kodama I, Tanabe T Intravenous amiodarone (AMD) induces multiple antiarrhythmic effects via blocking of Na(+), Ca(2+), and IKr channels, and beta receptors. A patient on chronic dialysis was administered AMD for nonsustained ventricular tachycardia after successful cardiopulmonary resuscitation. QT prolongation occurred 5h after AMD administration. AMD was withdrawn at 24h because of prolonged QTc interval (716ms), which persisted for a further 48h (661ms). Ventricular premature contraction (VPC) was significantly decreased at 7h; however, VPC increased again after discontinuing AMD. Depolarization changes induced by the Na(+)-channel blocking action of AMD were analyzed. There was increasing filtered QRS-...