http://kidneyfunction.org Renal Information Sun, 22 Jan 2012 23:48:20 +0000 en hourly 1 http://wordpress.org/?v=3.0.2 http://kidneyfunction.org/cyclophosphamide-therapy-for-corticoresistant-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-in-a-patient-with-severe-kidney-and-eye-involvement-and-epstein-barr-virus-reactiva/ http://kidneyfunction.org/cyclophosphamide-therapy-for-corticoresistant-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-in-a-patient-with-severe-kidney-and-eye-involvement-and-epstein-barr-virus-reactiva/#comments Thu, 28 Jan 2010 08:00:00 +0000 Emilie Laban, Eva Hainaut-Wierzbicka, François Pourreau, Mokrane Yacoub, Emilie Sztermer, Gérard Guillet, Guy Touchard, Frank Bridoux http://10.1053/j.ajkd.2009.10.054 DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe adverse drug reaction with significant mortality, characterized by erythroderma, fever, lymphadenopathy, and visceral involvement. We report a case of multivisceral DRESS syndrome with posterior multifocal placoid pigment epitheliopathy and acute tubulointerstitial nephritis responsible for dialysis-dependent acute kidney failure in the context of reactivation of Epstein-Barr virus infection. Because of resistance of the skin and kidney manifestations to prolonged corticosteroid therapy, a 6-month course of oral cyclophosphamide resulted in complete recovery of all symptoms. To our knowledge, this is the first case showing the efficacy of cyclophosphamide in severe DRESS syndrome.

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