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	<title>Kidney Function &#187; Deborah R. Zucker, Aneet Deo, Christopher H. Schmid</title>
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		<title>Dialysis Research and N-of-1 Trials: Made for Each Other? &#8211; Corrected Proof</title>
		<link>http://kidneyfunction.org/dialysis-research-and-n-of-1-trials-made-for-each-other-corrected-proof/</link>
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		<pubDate>Mon, 08 Feb 2010 03:00:00 +0000</pubDate>
		<dc:creator>Deborah R. Zucker, Aneet Deo, Christopher H. Schmid</dc:creator>
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		<guid isPermaLink="false">10.1053/j.ajkd.2009.11.010</guid>
		<description><![CDATA[The American Journal of Kidney Diseases Acid-Base and Electrolyte Teaching Case from Saito et al, which appeared in a recent issue of the journal, presents a teaching opportunity about research designs and in particular the use of single-subject (N-of-1 or N=1) trials. Saito et al observed instability in a patient with congenital methylmalonic acidemia during hemodialysis (HD) using an acetate-containing dialysate. Based on biochemistry, they assumed that this response likely was caused by the acetate. They tested an acetate-free citrate HD dialysate in the same patient and did not find this response. Their study looked to more rigorously compare the effectiveness of these 2 buffers and also to verify the connection between the observed adverse reactions (hypotension) and the acetate-based dialysate in this individual.]]></description>
			<content:encoded><![CDATA[The American Journal of Kidney Diseases Acid-Base and Electrolyte Teaching Case from Saito et al, which appeared in a recent issue of the journal, presents a teaching opportunity about research designs and in particular the use of single-subject (N-of-1 or N=1) trials. Saito et al observed instability in a patient with congenital methylmalonic acidemia during hemodialysis (HD) using an acetate-containing dialysate. Based on biochemistry, they assumed that this response likely was caused by the acetate. They tested an acetate-free citrate HD dialysate in the same patient and did not find this response. Their study looked to more rigorously compare the effectiveness of these 2 buffers and also to verify the connection between the observed adverse reactions (hypotension) and the acetate-based dialysate in this individual.]]></content:encoded>
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